40S ribosomal protein S5

Protein-coding gene in the species Homo sapiens
RPS5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC,%%s4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5A2Q, 4V6X, 4UJD, 3J7P, 5AJ0, 4KZZ, 4UG0, 4UJE, 4UJC, 5FLX

Identifiers
AliasesRPS5, S5, ribosomal protein S5
External IDsOMIM: 603630; MGI: 1097682; HomoloGene: 783; GeneCards: RPS5; OMA:RPS5 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RPS5
Genomic location for RPS5
Band19q13.43Start58,386,400 bp[1]
End58,394,806 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RPS5
Genomic location for RPS5
Band7|7 A1Start12,656,217 bp[2]
End12,660,613 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • vulva

  • trabecular bone

  • mucosa of sigmoid colon

  • skin of arm

  • human penis

  • left ovary

  • oral cavity

  • superficial temporal artery

  • skin of thigh
Top expressed in
  • Gonadal ridge

  • mandibular prominence

  • maxillary prominence

  • efferent ductule

  • internal carotid artery

  • somite

  • medial ganglionic eminence

  • precursor cell

  • migratory enteric neural crest cell

  • external carotid artery
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • protein binding
  • mRNA binding
  • RNA binding
  • rRNA binding
Cellular component
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • small ribosomal subunit
  • extracellular exosome
  • extracellular matrix
  • nucleoplasm
  • cytosolic small ribosomal subunit
  • ribonucleoprotein complex
Biological process
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • translational initiation
  • regulation of translational fidelity
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • rRNA processing
  • protein biosynthesis
  • ribosomal small subunit assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6193

20103

Ensembl

ENSG00000083845

ENSMUSG00000012848

UniProt

P46782

P97461

RefSeq (mRNA)

NM_001009

NM_009095

RefSeq (protein)

NP_001000
NP_001000.2

NP_033121

Location (UCSC)Chr 19: 58.39 – 58.39 MbChr 7: 12.66 – 12.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, in eukaryotes, consist of a small 40S subunit and a large 60S subunit (whereas prokaryotic ribosomes are 70 Svedberg units, composed of 50S and 30S subunits). They are located in the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the eukaryotic 40S subunit. The protein belongs to the S7P family of ribosomal proteins. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083845 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012848 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPS5 ribosomal protein S5".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID 8318536.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Malygin A, Baranovskaya O, Ivanov A, Karpova G (2003). "Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26". Protein Expr. Purif. 28 (1): 57–62. doi:10.1016/S1046-5928(02)00652-6. PMID 12651107.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.

External links

  • Overview of all the structural information available in the PDB for UniProt: P46782 (40S ribosomal protein S5) at the PDBe-KB.
  • v
  • t
  • e
Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e