BNIPL

Protein-coding gene in the species Homo sapiens
BNIPL
Identifiers
AliasesBNIPL, BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, BNIPS, PP753, BCL2/adenovirus E1B 19kD interacting protein like, BNIP-Salpha, BNIP-Sbeta, BCL2 interacting protein like
External IDsOMIM: 611275; MGI: 2384749; HomoloGene: 15900; GeneCards: BNIPL; OMA:BNIPL - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for BNIPL
Genomic location for BNIPL
Band1q21.3Start151,036,321 bp[1]
End151,047,720 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for BNIPL
Genomic location for BNIPL
Band3|3 F2.1Start95,148,582 bp[2]
End95,158,504 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • skin of abdomen

  • amniotic fluid

  • skin of leg

  • skin of thigh

  • skin of hip

  • gingival epithelium

  • oral cavity

  • mucosa of pharynx

  • buccal mucosa cell
Top expressed in
  • lip

  • esophagus

  • zone of skin

  • urinary bladder

  • urethra

  • female urethra

  • morula

  • male urethra

  • epithelium of urethra

  • epithelium of male urethra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
  • exopolyphosphatase activity
Cellular component
  • cytosol
  • nucleus
  • cytoplasm
Biological process
  • regulation of growth rate
  • negative regulation of cell population proliferation
  • apoptotic process
  • polyphosphate catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

149428

171388

Ensembl

ENSG00000163141

ENSMUSG00000028115

UniProt

Q7Z465

Q99JU7

RefSeq (mRNA)

NM_001159642
NM_138278
NM_138279

NM_001168356
NM_134253

RefSeq (protein)

NP_001153114
NP_612122

NP_001161828
NP_599014

Location (UCSC)Chr 1: 151.04 – 151.05 MbChr 3: 95.15 – 95.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene.[5][6][7]

Interactions

BNIPL has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163141 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028115 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, Li YY, Gu J (Apr 2003). "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER". FEBS Letters. 540 (1–3): 86–90. doi:10.1016/S0014-5793(03)00229-1. PMID 12681488.
  6. ^ Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (Mar 2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". The Journal of Biological Chemistry. 277 (9): 7483–92. doi:10.1074/jbc.M109459200. PMID 11741952.
  7. ^ "Entrez Gene: BNIPL BCL2/adenovirus E1B 19kD interacting protein like".
  8. ^ a b c Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications. 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
  9. ^ a b Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Research. 59 (3): 533–7. PMID 9973195.

External links

Further reading

  • Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications. 308 (2): 379–85. doi:10.1016/S0006-291X(03)01387-1. PMID 12901880.
  • Xie L, Qin WX, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (May 2004). "Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2". World Journal of Gastroenterology. 10 (9): 1286–91. doi:10.3748/wjg.v10.i9.1286. PMC 4622767. PMID 15112343.
  • Xie L, Qin WX, Li JJ, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (Sep 2005). "cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1". Acta Biochimica et Biophysica Sinica. 37 (9): 618–24. doi:10.1111/j.1745-7270.2005.00086.x. PMID 16143817.
  • Valencia CA, Cotten SW, Liu R (Dec 2007). "Cleavage of BNIP-2 and BNIP-XL by caspases". Biochemical and Biophysical Research Communications. 364 (3): 495–501. doi:10.1016/j.bbrc.2007.10.018. PMID 17961507.


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