CHTF18

Protein-coding gene in the species Homo sapiens
CHTF18
Identifiers
AliasesCHTF18, C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, chromosome transmission fidelity factor 18
External IDsOMIM: 613201; MGI: 2384887; HomoloGene: 32532; GeneCards: CHTF18; OMA:CHTF18 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CHTF18
Genomic location for CHTF18
Band16p13.3Start788,046 bp[1]
End800,737 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CHTF18
Genomic location for CHTF18
Band17|17 A3.3Start25,937,900 bp[2]
End25,946,393 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • mucosa of transverse colon

  • right hemisphere of cerebellum

  • pancreatic ductal cell

  • gonad

  • sural nerve

  • ventricular zone

  • ganglionic eminence

  • granulocyte
Top expressed in
  • epiblast

  • yolk sac

  • internal carotid artery

  • external carotid artery

  • morula

  • embryo

  • blastocyst

  • embryo

  • ventricular zone

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • DNA binding
  • single-stranded DNA helicase activity
  • protein binding
  • ATP binding
  • DNA clamp loader activity
Cellular component
  • membrane
  • Ctf18 RFC-like complex
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • DNA replication
  • cell cycle
  • positive regulation of DNA-directed DNA polymerase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

63922

214901

Ensembl

ENSG00000127586

ENSMUSG00000019214

UniProt

Q8WVB6

Q8BIW9

RefSeq (mRNA)

NM_022092

NM_145409

RefSeq (protein)

NP_071375

NP_663384

Location (UCSC)Chr 16: 0.79 – 0.8 MbChr 17: 25.94 – 25.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.[5][6]

Interactions

CHTF18 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127586 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019214 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  6. ^ "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)".
  7. ^ a b c d e Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  8. ^ a b c Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.

External links

Further reading

  • Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T (Jul 2007). "A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity". The Journal of Biological Chemistry. 282 (29): 20906–14. doi:10.1074/jbc.M610102200. PMID 17545166.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  • Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  • Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K (Sep 2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Molecular and Cellular Biology. 21 (17): 5838–45. doi:10.1128/MCB.21.17.5838-5845.2001. PMC 87303. PMID 11486023.
  • Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
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