Diazepam binding inhibitor

Protein-coding gene in the species Homo sapiens
DBI
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2FJ9, 2CB8

Identifiers
AliasesDBI, ACBD1, ACBP, CCK-RP, EP, Diazepam binding inhibitor, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor, acyl-CoA binding protein
External IDsOMIM: 125950; MGI: 94865; HomoloGene: 39086; GeneCards: DBI; OMA:DBI - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DBI
Genomic location for DBI
Band2q14.2Start119,366,924 bp[1]
End119,372,550 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DBI
Genomic location for DBI
Band1|1 E2.3Start120,041,010 bp[2]
End120,048,808 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vulva

  • mucosa of transverse colon

  • gingival epithelium

  • sperm

  • skin of thigh

  • oral cavity

  • mucosa of pharynx

  • human penis

  • skin of hip

  • ventricular zone
Top expressed in
  • optic nerve

  • brown adipose tissue

  • white adipose tissue

  • right kidney

  • subcutaneous adipose tissue

  • tunica adventitia of aorta

  • lactiferous gland

  • medial ganglionic eminence

  • ventricular zone

  • Epithelium of choroid plexus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • benzodiazepine receptor binding
  • lipid binding
  • long-chain fatty acyl-CoA binding
  • fatty-acyl-CoA binding
  • protein dimerization activity
Cellular component
  • Golgi apparatus
  • perinuclear endoplasmic reticulum
  • extracellular exosome
  • endoplasmic reticulum
  • endoplasmic reticulum lumen
Biological process
  • protein palmitoylation
  • phosphatidylcholine acyl-chain remodeling
  • acyl-CoA metabolic process
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1622

13167

Ensembl

ENSG00000155368

ENSMUSG00000026385

UniProt

P07108

P31786

RefSeq (mRNA)
NM_001079862
NM_001079863
NM_001178017
NM_001178041
NM_001178042

NM_001178043
NM_001282633
NM_001282634
NM_001282635
NM_001282636
NM_020548
NM_001352432

NM_001037999
NM_007830

RefSeq (protein)
NP_001073331
NP_001073332
NP_001171488
NP_001171512
NP_001171513

NP_001171514
NP_001269562
NP_001269563
NP_001269564
NP_001269565
NP_065438
NP_001339361

NP_001033088
NP_031856

Location (UCSC)Chr 2: 119.37 – 119.37 MbChr 1: 120.04 – 120.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.[5][6]

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155368 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026385 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Todd S, Naylor SL (Dec 1992). "New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene". Somat Cell Mol Genet. 18 (4): 381–385. doi:10.1007/BF01235761. PMID 1440058. S2CID 46694856.
  6. ^ a b "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)".

Further reading

  • Papadopoulos V, Brown AS (1995). "Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis". J. Steroid Biochem. Mol. Biol. 53 (1–6): 103–110. doi:10.1016/0960-0760(95)00027-W. PMID 7626442. S2CID 41277281.
  • Costa E, Auta J, Guidotti A, et al. (1994). "The pharmacology of neurosteroidogenesis". J. Steroid Biochem. Mol. Biol. 49 (4–6): 385–389. doi:10.1016/0960-0760(94)90284-4. PMID 8043504. S2CID 33492066.
  • Mandrup S, Hummel R, Ravn S, et al. (1993). "Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family". J. Mol. Biol. 228 (3): 1011–1022. doi:10.1016/0022-2836(92)90888-Q. PMID 1469708.
  • Webb NR, Rose TM, Malik N, et al. (1987). "Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand". DNA. 6 (1): 71–79. doi:10.1089/dna.1987.6.71. PMID 2881742.
  • Gray PW, Glaister D, Seeburg PH, et al. (1986). "Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor". Proc. Natl. Acad. Sci. U.S.A. 83 (19): 7547–7551. Bibcode:1986PNAS...83.7547G. doi:10.1073/pnas.83.19.7547. PMC 386756. PMID 3020548.
  • DeBernardi MA, Crowe RR, Mocchetti I, et al. (1988). "Chromosomal localization of the human diazepam binding inhibitor gene". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6561–6565. Bibcode:1988PNAS...85.6561D. doi:10.1073/pnas.85.17.6561. PMC 282013. PMID 3413112.
  • Marquardt H, Todaro GJ, Shoyab M (1986). "Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor". J. Biol. Chem. 261 (21): 9727–9731. doi:10.1016/S0021-9258(18)67575-1. PMID 3525533.
  • Swinnen JV, Esquenet M, Heyns W, et al. (1995). "Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP". Mol. Cell. Endocrinol. 104 (2): 153–162. doi:10.1016/0303-7207(94)90118-X. PMID 7527352. S2CID 29195251.
  • Kolmer M, Rovio A, Alho H (1995). "The characterization of two diazepam binding inhibitor (DBI) transcripts in humans". Biochem. J. 306 (Pt 2): 327–330. doi:10.1042/bj3060327. PMC 1136524. PMID 7534063.
  • Gersuk VH, Rose TM, Todaro GJ (1995). "Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor". Genomics. 25 (2): 469–476. doi:10.1016/0888-7543(95)80047-P. PMID 7789980.
  • Alho H, Kolmer M, Harjuntausta T, Helén P (1995). "Increased expression of diazepam binding inhibitor in human brain tumors". Cell Growth Differ. 6 (3): 309–314. PMID 7794798.
  • Alho H, Vaalasti A, Podkletnova I, Rechardt L (1994). "Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study". J. Invest. Dermatol. 101 (6): 800–803. doi:10.1111/1523-1747.ep12371698. PMID 8245508.
  • Cavallaro S, Pani L, Guidotti A, Costa E (1993). "ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action". Life Sci. 53 (14): 1137–1147. doi:10.1016/0024-3205(93)90550-M. PMID 8396705.
  • Swinnen JV, Esquenet M, Rosseels J, et al. (1996). "A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP". DNA Cell Biol. 15 (3): 197–208. doi:10.1089/dna.1996.15.197. PMID 8634149.
  • Krøll JB, Nøhr J, Gregersen N, et al. (1996). "Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum". Gene. 173 (2): 239–240. doi:10.1016/0378-1119(96)00214-4. PMID 8964506.
  • Kolmer M, Pelto-Huikko M, Parvinen M, et al. (1997). "The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells". DNA Cell Biol. 16 (1): 59–72. doi:10.1089/dna.1997.16.59. PMID 9022045.
  • Ferrarese C, Cogliati T, Tortorella R, et al. (1998). "Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients". Epilepsy Res. 29 (2): 129–134. doi:10.1016/S0920-1211(97)00074-0. PMID 9477145. S2CID 2832298.


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  • 1aca: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN ACYL-COENZYME A BINDING PROTEIN AND PALMITOYL-COENZYME A
    1aca: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN ACYL-COENZYME A BINDING PROTEIN AND PALMITOYL-COENZYME A
  • 1hb6: STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN ORTHORHOMBIC CRYSTAL FORM
    1hb6: STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN ORTHORHOMBIC CRYSTAL FORM
  • 1hb8: STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN TETRAGONAL CRYSTAL FORM
    1hb8: STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN TETRAGONAL CRYSTAL FORM
  • 1nti: RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP
    1nti: RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP
  • 1nvl: RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP, in complex with palmitoyl-coenzyme A
    1nvl: RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP, in complex with palmitoyl-coenzyme A
  • 2abd: THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY
    2abd: THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY
  • 2cb8: HIGH RESOLUTION CRYSTAL STRUCTURE OF LIGANDED HUMAN L-ACBP
    2cb8: HIGH RESOLUTION CRYSTAL STRUCTURE OF LIGANDED HUMAN L-ACBP
  • 2fj9: High resolution crystal structure of the unliganded human ACBP
    2fj9: High resolution crystal structure of the unliganded human ACBP


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