Protein-coding gene in the species Homo sapiens
DUSP8 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | DUSP8, C11orf81, HB5, HVH-5, HVH8, dual specificity phosphatase 8 |
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External IDs | OMIM: 602038; MGI: 106626; HomoloGene: 31239; GeneCards: DUSP8; OMA:DUSP8 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11p15.5 | Start | 1,554,051 bp[1] |
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End | 1,572,271 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 F5|7 87.59 cM | Start | 141,633,227 bp[2] |
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End | 141,649,580 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gastric mucosa
- superior frontal gyrus
- prefrontal cortex
- nucleus accumbens
- putamen
- temporal lobe
- amygdala
- hippocampus proper
- dorsolateral prefrontal cortex
- caudate nucleus
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| Top expressed in | - subiculum
- Region I of hippocampus proper
- superior frontal gyrus
- olfactory tubercle
- dorsal tegmental nucleus
- nucleus accumbens
- cerebellar cortex
- medial geniculate nucleus
- cerebellar vermis
- olfactory bulb
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - MAP kinase tyrosine/serine/threonine phosphatase activity
- phosphoprotein phosphatase activity
- hydrolase activity
- protein tyrosine/serine/threonine phosphatase activity
- phosphatase activity
- protein tyrosine phosphatase activity
| Cellular component | - nucleus
- cytoplasm
- cytosol
| Biological process | - protein dephosphorylation
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000184545 ENSG00000273793 ENSG00000278165 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 1.55 – 1.57 Mb | Chr 7: 141.63 – 141.65 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. [5]
Function
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
References
- ^ a b c ENSG00000273793, ENSG00000278165 GRCh38: Ensembl release 89: ENSG00000184545, ENSG00000273793, ENSG00000278165 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037887 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Dual specificity phosphatase 8". Retrieved 2017-09-08.
Further reading
- Hink RL, Hokanson JE, Shah I, Long JC, Goldman D, Sikela JM (2003). "Investigation of DUSP8 and CALCA in alcohol dependence". Addict Biol. 8 (3): 305–312. doi:10.1080/13556210310001602211. PMID 13129832. S2CID 30875223.
- Berger IR, Buschbeck M, Bange J, Ullrich A (2005). "Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2". Cancer Genet. Cytogenet. 159 (2): 155–159. doi:10.1016/j.cancergencyto.2004.10.010. PMID 15899389.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.