ESCO1

Protein-coding gene in the species Homo sapiens
ESCO1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4MXE

Identifiers
AliasesESCO1, A930014I12Rik, CTF, ECO1, EFO1, ESO1, establishment of sister chromatid cohesion N-acetyltransferase 1
External IDsOMIM: 609674; MGI: 1925055; HomoloGene: 62166; GeneCards: ESCO1; OMA:ESCO1 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ESCO1
Genomic location for ESCO1
Band18q11.2Start21,529,284 bp[1]
End21,600,884 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for ESCO1
Genomic location for ESCO1
Band18|18 A1Start10,566,507 bp[2]
End10,610,352 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • tendon of biceps brachii

  • pancreatic epithelial cell

  • tibialis anterior muscle

  • secondary oocyte

  • Achilles tendon

  • deltoid muscle

  • testicle

  • gonad

  • epithelium of nasopharynx
Top expressed in
  • saccule

  • zygote

  • primary oocyte

  • secondary oocyte

  • otic placode

  • otic vesicle

  • mesenteric lymph nodes

  • lacrimal gland

  • cumulus cell

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • acyltransferase activity
  • metal ion binding
  • N-acetyltransferase activity
  • zinc ion binding
  • peptide-lysine-N-acetyltransferase activity
  • identical protein binding
  • acetyltransferase activity
Cellular component
  • chromatin
  • nucleus
  • nucleoplasm
  • chromosome
Biological process
  • post-translational protein acetylation
  • cell cycle
  • sister chromatid cohesion
  • regulation of DNA replication
  • peptidyl-lysine acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114799

77805

Ensembl

ENSG00000141446

ENSMUSG00000024293

UniProt

Q5FWF5

Q69Z69

RefSeq (mRNA)

NM_052911

NM_001081222
NM_144542

RefSeq (protein)

NP_443143

NP_001074691

Location (UCSC)Chr 18: 21.53 – 21.6 MbChr 18: 10.57 – 10.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Establishment of sister chromatid cohesion N-acetyltransferase 1 is a protein that in humans is encoded by the ESCO1 gene.[5]

Function

ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141446 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024293 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Establishment of sister chromatid cohesion N-acetyltransferase 1". Retrieved 2015-09-17.
  6. ^ Hou F, Zou H (2005). "Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion". Molecular Biology of the Cell. 16 (8): 3908–18. doi:10.1091/mbc.E04-12-1063. PMC 1182326. PMID 15958495.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human N-acetyltransferase ESCO1


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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