Ilepcimide
Chemical compound
- none
- (2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)prop-2-en-1-one
- 82857-82-7
Y
- 641115
- 556435
N
- 5ML58O200F
- Interactive image
- C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3
InChI
- InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+N
- Key:BLPUOQGPBJPXRL-FNORWQNLSA-NN
N
Y (what is this?) (verify)Ilepcimide, also known as antiepilepserine, is an anticonvulsant.[1] It is a piperidine derivative that was first synthesized by Chinese researchers as an analogue of piperine, the main pungent compound and phytochemical of black pepper (and of other plants in the family Piperaceae).
Ilepcimide has serotonergic activity.[1][2][3]
See also
- Black pepper
References
- ^ a b Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012.
- ^ Liu GQ, Algeri S, Ceci A, Garattini S, Gobbi M, Murai S (December 1984). "Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative". Biochemical Pharmacology. 33 (23): 3883–6. doi:10.1016/0006-2952(84)90055-8. PMID 6210090.
- ^ Yan QS, Mishra PK, Burger RL, Bettendorf AF, Jobe PC, Dailey JW (May 1992). "Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats". The Journal of Pharmacology and Experimental Therapeutics. 261 (2): 652–9. PMID 1374472.
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Anticonvulsants (N03)
modulators
| CA inhibitors |
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| Others |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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