Luzindole

Chemical compound
  • None
Legal statusLegal status
  • In general: non-regulated
Identifiers
  • N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide
CAS Number
  • 117946-91-5 checkY
PubChem CID
  • 122162
ChemSpider
  • 108959
UNII
  • B31Y10A9UR
ChEBI
  • CHEBI:131788 checkY
CompTox Dashboard (EPA)
  • DTXSID40151969 Edit this at Wikidata
Chemical and physical dataFormulaC19H20N2OMolar mass292.382 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(NCCc2c1ccccc1[nH]c2Cc3ccccc3)C
InChI
  • InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
  • Key:WVVXBPKOIZGVNS-UHFFFAOYSA-N

Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist,[1] with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor.[2][3] In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.[2][4]

References

  1. ^ Dubocovich ML (September 1988). "Luzindole (N-0774): a novel melatonin receptor antagonist". The Journal of Pharmacology and Experimental Therapeutics. 246 (3): 902–10. PMID 2843633.
  2. ^ a b Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI (September 1998). "Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms". The FASEB Journal. 12 (12): 1211–20. doi:10.1096/fasebj.12.12.1211. PMID 9737724. S2CID 566199.
  3. ^ Browning C, Beresford I, Fraser N, Giles H (March 2000). "Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors". British Journal of Pharmacology. 129 (5): 877–86. doi:10.1038/sj.bjp.0703130. PMC 1571913. PMID 10696085.
  4. ^ Dubocovich ML, Mogilnicka E, Areso PM (July 1990). "Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test". European Journal of Pharmacology. 182 (2): 313–25. doi:10.1016/0014-2999(90)90290-M. PMID 2168835.
  • v
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MT1Tooltip Melatonin receptor 1MT2Tooltip Melatonin receptor 2Unsorted
  • Agonists: 2-Phenylmelatonin
  • 5-Methoxyluzindole
  • 6-Chloromelatonin
  • 6-Fluoromelatonin
  • 6-Methoxymelatonin
  • 6,7-Dichloro-2-methylmelatonin
  • 8-M-PDOT
  • AMMTC
  • GR-135,531 (of MT3Tooltip melatonin receptor 1C)
  • N-Acetyltryptamine
  • N-Butanoylmelatonin
  • N-Propionylmelatonin
  • S-24268
  • S-25150
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Dopaminergics
  • Serotonergics
  • Monoamine metabolism modulators
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