RAI2

Protein-coding gene in the species Homo sapiens
RAI2
Identifiers
AliasesRAI2, retinoic acid induced 2
External IDsOMIM: 300217; MGI: 1344378; HomoloGene: 11034; GeneCards: RAI2; OMA:RAI2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RAI2
Genomic location for RAI2
BandXp22.13Start17,800,049 bp[1]
End17,861,337 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for RAI2
Genomic location for RAI2
BandX|X F4Start160,500,065 bp[2]
End160,562,492 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left uterine tube

  • urethra

  • right lung

  • canal of the cervix

  • body of uterus

  • saphenous vein

  • gastric mucosa

  • left ovary

  • vena cava

  • decidua
Top expressed in
  • myocardium of ventricle

  • intercostal muscle

  • cumulus cell

  • supraoptic nucleus

  • pineal gland

  • aortic valve

  • muscle of thigh

  • islet of Langerhans

  • Rostral migratory stream

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cellular component
Biological process
  • embryo development ending in birth or egg hatching
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10742

24004

Ensembl

ENSG00000131831

ENSMUSG00000043518

UniProt

Q9Y5P3

Q9QVY8

RefSeq (mRNA)

NM_001172732
NM_001172739
NM_001172743
NM_021785

NM_001103367
NM_198409

RefSeq (protein)
NP_001166203
NP_001166210
NP_001166214
NP_068557
NP_001166210.1

NP_001166214.1
NP_068557.3

NP_001096837
NP_940801

Location (UCSC)Chr X: 17.8 – 17.86 MbChr X: 160.5 – 160.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.[5][6][7]

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131831 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043518 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
  6. ^ Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933. S2CID 5675053.
  7. ^ a b "Entrez Gene: RAI2 retinoic acid induced 2".

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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