Thonzylamine

Chemical compound
  • D04AA01 (WHO) R01AC06 (WHO) R06AC06 (WHO)
Identifiers
  • N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
CAS Number
  • 91-85-0 ☒N 63-56-9
PubChem CID
  • 5457
ChemSpider
  • 5258 checkY
UNII
  • R79646H5Z8
KEGG
  • D08587 checkY
ChEMBL
  • ChEMBL1623738 ☒N
CompTox Dashboard (EPA)
  • DTXSID8043864 Edit this at Wikidata
ECHA InfoCard100.001.913 Edit this at WikidataChemical and physical dataFormulaC16H22N4OMolar mass286.379 g·mol−13D model (JSmol)
  • Interactive image
  • n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2
InChI
  • InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 checkY
  • Key:GULNIHOSWFYMRN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Thonzylamine (or neohetramine)[1] is an antihistamine and anticholinergic used as an antipruritic.

Synthesis

Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, U.S. patent 2,465,865 (1949).

See also

  • Zolamine

References

  1. ^ Arminio JJ, Sweet CC (December 1949). "The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride)". Industrial Medicine & Surgery. 18 (12): 509–11. PMID 15393969.
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Decongestants and other nasal preparations (R01)
Topical
Sympathomimetics, plain
Antiallergic agents,
excluding corticosteroids
Corticosteroids
Other nasal preparations
Combination products
Systemic use:
Sympathomimetics
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Benzimidazoles (*)
Diarylmethanes
Ethylenediamines
Tricyclics
Others
For topical use
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mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(and PAMsTooltip positive allosteric modulators)
Antagonists
(and NAMsTooltip negative allosteric modulators)
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Muscarinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators
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H1
Agonists
Antagonists
  • Unknown/unsorted: Azanator
  • Belarizine
  • Elbanizine
  • Flotrenizine
  • GSK1004723
  • Napactadine
  • Tagorizine
  • Trelnarizine
  • Trenizine
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors
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