UBE3C

Protein-coding gene in the species Homo sapiens
UBE3C
Identifiers
AliasesUBE3C, HECTH2, ubiquitin protein ligase E3C, RAUL
External IDsOMIM: 614454; MGI: 2140998; HomoloGene: 8783; GeneCards: UBE3C; OMA:UBE3C - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for UBE3C
Genomic location for UBE3C
Band7q36.3Start157,138,916 bp[1]
End157,269,370 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for UBE3C
Genomic location for UBE3C
Band5|5 B1Start29,774,240 bp[2]
End29,881,090 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • Achilles tendon

  • islet of Langerhans

  • epithelium of colon

  • gastrocnemius muscle

  • muscle of thigh

  • stromal cell of endometrium

  • gingival epithelium

  • Skeletal muscle tissue of biceps brachii

  • rectum
Top expressed in
  • spermatocyte

  • muscle of thigh

  • spermatid

  • dentate gyrus of hippocampal formation granule cell

  • tail of embryo

  • facial motor nucleus

  • triceps brachii muscle

  • cumulus cell

  • trigeminal ganglion

  • primary visual cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-protein transferase activity
  • transferase activity
  • ubiquitin protein ligase activity
  • ubiquitin conjugating enzyme activity
Cellular component
  • proteasome complex
  • intracellular anatomical structure
  • nucleus
  • cytoplasm
Biological process
  • protein polyubiquitination
  • protein ubiquitination
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9690

100763

Ensembl

ENSG00000009335

ENSMUSG00000039000

UniProt

Q15386

Q80U95

RefSeq (mRNA)

NM_014671

NM_133907

RefSeq (protein)

NP_055486

NP_598668

Location (UCSC)Chr 7: 157.14 – 157.27 MbChr 5: 29.77 – 29.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000009335 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039000 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  6. ^ You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi:10.1074/jbc.M100034200. PMID 11278995.
  7. ^ "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi:10.1074/jbc.M212887200. PMID 12692129.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.


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