Kolagenaza

matriks metalopeptidaza 1 (međuprostorna kolagenaza)
Identifikatori
Simbol MMP1
Entrez 4312
Hugo 7155
OMIM 120353
RefSek NM_002421
UniProt P03956
Drugi podaci
EC broj 3.4.24.7
Lokus Hrom. 11 q21-q22
matriks metalopeptidaza 8 (neutrofilna kolagenaza)
Identifikatori
Simbol MMP8
Entrez 4317
Hugo 7175
OMIM 120355
RefSek NM_002424
UniProt P22894
Drugi podaci
EC broj 3.4.24.34
Lokus Hrom. 11 q21-q22

Kolagenaze su enzimi koji razlažu peptidne veze kolagena. Oni pomažu u degradaciji ekstracelularnih struktura pri patogenezi bakterija kao što je Clostridium. Oni se smatraju faktorom virulencije koji omogućava širenje gasne gangrene. Oni normalno deluju na vezivno tkivo mišićnih ćelija i drugih organa.[1].[2][3][4][5]

Reference

  1. ↑ Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 0-321-39603-0. 
  2. ↑ Norris DB, Trudgill PW: Multiple forms of cyclohexanone oxygenase from Nocardia globerula CL1. Eur J Biochem. 1976 Mar 16;63(1):193-8. PMID 4312
  3. ↑ Pajot P: Fluroescence of proteins in 6-M guanidine hydrochloride. A method for the quantitative determination of tryptophan. Eur J Biochem. 1976 Mar 16;63(1):263-9. PMID 4317
  4. ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  5. ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 
  • Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 0-321-39603-0. 

Spoljašnje veze

Kolagenaza na Wikimedijinoj ostavi
  • Collagenase