PPP1R9B

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Protein fosfataza 1, regulatorna podjedinica 9B

PDB prikaz baziran na 2g5m.

Identifikatori

Simboli

PPP1R9B; PPP1R6; PPP1R9; SPINO; Spn

Vanjski ID

OMIM: 603325 MGI: 2387581 HomoloGene: 32787 GeneCards: PPP1R9B Gene

Ontologija gena
Molekularna funkcija	• vezivanje aktina • inhibitor proteinske fosfataze • proteinsko vezivanje • vezivanje proteinske fosfataze 1
Celularna komponenta	• kompleks proteinske fosfataze tipa 1 • nukleus • nukleoplazma • citoplazma • citoskeleton • ćelijska membrana • adhezioni spoj • lamelipodijum • filopodijum • rufl membrana • dendritska izbočina • sinapsa
Biološki proces	• regulacija ćelijskog rasta ekstraćelijskim stimulusom • zaustavljanje ćelijskog ciklusa • regulacija ćelijske proliferacije • filopodijumska struktura • ćelijski respons na morfin • regulacija signalnog puta opioidnog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

84687

217124

Ensembl

ENSG00000108819

ENSMUSG00000038976

UniProt

Q96SB3

Q6R891

RefSeq (mRNA)

NM_032595.3

NM_172261.3

RefSeq (protein)

NP_115984.3

NP_758465.2

Lokacija (UCSC)

Chr 17:
45.57 - 45.58 Mb

Chr 11:
94.85 - 94.87 Mb

PubMed pretraga

[1]

[2]

Neurabin-2 je protein koji je kod ljudi kodiran PPP1R9B genom.^[1]^[2]

Spinofilin je regulatorni deo katalitičke jedinica proteinske fosfataze-1 (PP1). On je visoko izražen u dendritskim izbočinama, specijalizoanim delovima koji primaju veći deo ekscitatornog unosa u centralnom nervnom sistemu.^[2]

Interakcije

PPP1R9B formira interakcije sa PPP1CB,^[3] PPP1CA,^[3] Dopamine receptor D2,^[4] P16,^[5] PPP1CC,^[3]^[4] TIAM1^[6] i PPP1R2.^[7]

Reference

↑ Allen PB, Ouimet CC, Greengard P (Oct 1997). „Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines”. Proc Natl Acad Sci U S A 94 (18): 9956–61. DOI:10.1073/pnas.94.18.9956. PMC 23308. PMID 9275233.
↑ ^2,0 ^2,1 „Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B”.
↑ ^3,0 ^3,1 ^3,2 Hsieh-Wilson, L C; Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry (UNITED STATES) 38 (14): 4365–73. DOI:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
↑ ^4,0 ^4,1 Smith, F D; Oxford G S, Milgram S L (July 1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. (UNITED STATES) 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.
↑ Vivo, M; Calogero R A, Sansone F, Calabrò V, Parisi T, Borrelli L, Saviozzi S, La Mantia G (April 2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. (United States) 276 (17): 14161–9. DOI:10.1074/jbc.M006845200. ISSN 0021-9258. PMID 11278317.
↑ Buchsbaum, Rachel J; Connolly Beth A, Feig Larry A (May 2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. (United States) 278 (21): 18833–41. DOI:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897.
↑ Terry-Lorenzo, Ryan T; Elliot Elizabeth, Weiser Douglas C, Prickett Todd D, Brautigan David L, Shenolikar Shirish (November 2002). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. (United States) 277 (48): 46535–43. DOI:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.

Literatura

Burnett PE, Blackshaw S, Lai MM, et al. (1998). „Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton”. Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351–6. DOI:10.1073/pnas.95.14.8351. PMC 20979. PMID 9653190.
Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry 38 (14): 4365–73. DOI:10.1021/bi982900m. PMID 10194355.
Smith FD, Oxford GS, Milgram SL (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. PMID 10391935.
Stephens DJ, Banting G (1999). „Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin”. J. Biol. Chem. 274 (42): 30080–6. DOI:10.1074/jbc.274.42.30080. PMID 10514494.
Richman JG, Brady AE, Wang Q, et al. (2001). „Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin”. J. Biol. Chem. 276 (18): 15003–8. DOI:10.1074/jbc.M011679200. PMID 11154706.
Vivo M, Calogero RA, Sansone F, et al. (2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. 276 (17): 14161–9. DOI:10.1074/jbc.M006845200. PMID 11278317.
Grossman SD, Hsieh-Wilson LC, Allen PB, et al. (2003). „The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines”. Neuromolecular Med. 2 (1): 61–9. DOI:10.1385/NMM:2:1:61. PMID 12230305.
Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. 277 (48): 46535–43. DOI:10.1074/jbc.M206960200. PMID 12270929.
Hsieh-Wilson LC, Benfenati F, Snyder GL, et al. (2003). „Phosphorylation of spinophilin modulates its interaction with actin filaments”. J. Biol. Chem. 278 (2): 1186–94. DOI:10.1074/jbc.M205754200. PMID 12417592.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Buchsbaum RJ, Connolly BA, Feig LA (2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. 278 (21): 18833–41. DOI:10.1074/jbc.M207876200. PMID 12531897.
Tsukada M, Prokscha A, Oldekamp J, Eichele G (2004). „Identification of neurabin II as a novel doublecortin interacting protein”. Mech. Dev. 120 (9): 1033–43. DOI:10.1016/S0925-4773(03)00177-1. PMID 14550532.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Law AJ, Weickert CS, Hyde TM, et al. (2004). „Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines”. The American journal of psychiatry 161 (10): 1848–55. DOI:10.1176/appi.ajp.161.10.1848. PMID 15465982.