LHX2
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| 識別號 | |||||||||||||||||||||||||
| 别名 | LHX2；, LH2, hLhx2, LIM homeobox 2 | ||||||||||||||||||||||||
| 外部ID | OMIM：603759 MGI：96785 HomoloGene：55848 GeneCards：LHX2 | ||||||||||||||||||||||||
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| 直系同源 | |||||||||||||||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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| 蛋白序列 |
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| 基因位置（UCSC） | Chr 9: 124 – 124.03 Mb | Chr 2: 38.23 – 38.26 Mb | |||||||||||||||||||||||
| PubMed查找 | [3] | [4] | |||||||||||||||||||||||
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LIM同源框蛋白質 LHX2是蛋白質的一種，在人類內由「LHX2」基因所編碼。[5][6][7]
LHX2包含LIM結構域，这是一種帶有許多半胱氨酸，具鋅指結構的結構域。該蛋白質的作用為轉錄調控。該蛋白質在果蠅體內，可用來回復由其他蛋白質引起的表型，推測是在演化時留下的功能[7]。
交互作用
參考資料
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene. Jul 1996, 12 (6): 1205–12. PMID 8649822.
- ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. Apr 1999, 96 (5): 2165–70. PMC 26754
. PMID 10051612. doi:10.1073/pnas.96.5.2165. - ^ 7.0 7.1 Entrez Gene: LHX2 LIM homeobox 2.
- ^ Glenn, D J; Maurer R A. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. (UNITED STATES). Dec 1999, 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900. doi:10.1074/jbc.274.51.36159.
延伸閱讀
- Gerhard DS, Wagner L, Feingold EA et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 引文格式1维护：显式使用等标签 (link)
- Ota T, Suzuki Y, Nishikawa T et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 引文格式1维护：显式使用等标签 (link)
- Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 引文格式1维护：显式使用等标签 (link)
- Glenn DJ, Maurer RA. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 2000, 274 (51): 36159–67. PMID 10593900. doi:10.1074/jbc.274.51.36159.
- Bach I, Rodriguez-Esteban C, Carrière C et al. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 1999, 22 (4): 394–9. PMID 10431247. doi:10.1038/11970. 引文格式1维护：显式使用等标签 (link)
- Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation. 1998, 63 (3): 151–7. PMID 9697309. doi:10.1046/j.1432-0436.1998.6330151.x.
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