CLCA3

Pseudogene in the species Homo sapiens

CLCA3P

Identifiers

Aliases

CLCA3P, CLCA3, chloride channel accessory 3, pseudogene

External IDs

OMIM: 604337; GeneCards: CLCA3P; OMA:CLCA3P - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p22.3	Start	86,634,273 bp^[1]
Band	1p22.3	End	86,655,376 bp^[1]

Gene ontology
Molecular function	voltage-gated ion channel activity chloride channel activity calcium channel activity transporter activity metalloendopeptidase activity
Cellular component	extracellular region plasma membrane chloride channel complex extracellular space
Biological process	calcium ion transport ion transmembrane transport regulation of ion transmembrane transport chloride transport chloride transmembrane transport ion transport calcium ion transmembrane transport proteolysis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9629


n/a

Ensembl


ENSG00000153923


n/a

UniProt


Q9Y6N3


n/a

RefSeq (mRNA)


NM_004921


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 1: 86.63 – 86.66 Mb

n/a

PubMed search

^[2]

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Wikidata

View/Edit Human

Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.^[3] According to the HGNC, this protein is not expressed in humans but is in certain other species such as mouse. However, some conflicting reports state that human cells produce and glycosylate this protein.^[3]

Function

This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153923 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels". Biochimica et Biophysica Acta. 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065.
^ Pawłowski K, Lepistö M, Meinander N, Sivars U, Varga M, Wieslander E (May 2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

External links

CLCA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin