KCNK16

Protein-coding gene in the species Homo sapiens

KCNK16

Identifiers

Aliases

KCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16

External IDs

OMIM: 607369; MGI: 1921821; HomoloGene: 75328; GeneCards: KCNK16; OMA:KCNK16 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.2	Start	39,314,698 bp^[1]
Band	6p21.2	End	39,322,968 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 A3\|14	Start	20,311,444 bp^[2]
Band	14 A3\|14	End	20,319,267 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

body of pancreas

duodenum

body of stomach

fundus

left lobe of thyroid gland

ascending aorta

right lung

right lobe of thyroid gland

intestinal epithelium

Top expressed in

islet of Langerhans

yolk sac

stomach

hair follicle

skin of abdomen

skin of back

duodenum

submandibular gland

liver

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity
Cellular component	integral component of membrane plasma membrane membrane integral component of plasma membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport stabilization of membrane potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


83795


74571

Ensembl


ENSG00000095981


ENSMUSG00000023387

UniProt


Q96T55


G5E845

RefSeq (mRNA)


NM_001135105 NM_001135106 NM_001135107 NM_032115 NM_001363784


NM_029006

RefSeq (protein)


NP_001128577 NP_001128578 NP_001128579 NP_115491 NP_001350713


NP_083282

Location (UCSC)

Chr 6: 39.31 – 39.32 Mb

Chr 14: 20.31 – 20.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.^[5]^[6] The protein encoded by this gene, K_2P16.1, is a potassium channel containing two pore-forming P domains.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095981 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023387 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
^ ^a ^b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

External links

KCNK16+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin