PHF20

Protein-coding gene in the species Homo sapiens
PHF20
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3P8D, 3Q1J, 3QII, 3SD4

Identifiers
AliasesPHF20, C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP, PHD finger protein 20
External IDsOMIM: 610335; MGI: 2444148; HomoloGene: 9507; GeneCards: PHF20; OMA:PHF20 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PHF20
Genomic location for PHF20
Band20q11.22-q11.23Start35,771,974 bp[1]
End35,950,370 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PHF20
Genomic location for PHF20
Band2|2 H1Start156,196,466 bp[2]
End156,309,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • sperm

  • epithelium of colon

  • Achilles tendon

  • Brodmann area 23

  • germinal epithelium

  • amniotic fluid

  • glutes

  • visceral pleura

  • parietal pleura
Top expressed in
  • zygote

  • ectoderm

  • otic placode

  • otic vesicle

  • saccule

  • primary oocyte

  • secondary oocyte

  • Region I of hippocampus proper

  • cerebellar vermis

  • lobe of cerebellum
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • histone acetyltransferase activity (H4-K8 specific)
  • DNA binding
  • histone acetyltransferase activity (H4-K5 specific)
  • metal ion binding
  • histone acetyltransferase activity (H4-K16 specific)
  • protein binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nuclear membrane
  • histone acetyltransferase complex
  • nucleus
  • nucleoplasm
  • cytosol
  • MLL1 complex
Biological process
  • histone H4-K16 acetylation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • histone H4-K5 acetylation
  • histone H4-K8 acetylation
  • regulation of signal transduction by p53 class mediator
  • chromatin organization
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51230

228829

Ensembl

ENSG00000025293

ENSMUSG00000038116

UniProt

Q9BVI0
Q5JWZ0

Q8BLG0

RefSeq (mRNA)

NM_016436

NM_172674

RefSeq (protein)

NP_057520

NP_766262

Location (UCSC)Chr 20: 35.77 – 35.95 MbChr 2: 156.2 – 156.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 20 is a protein that in humans is encoded by the PHF20 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025293 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038116 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PHF20 PHD finger protein 20".

Further reading

  • Fischer U, Struss AK, Hemmer D, Pallasch CP, Steudel WI, Meese E (November 2001). "Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls". Clin. Exp. Immunol. 126 (2): 206–13. doi:10.1046/j.1365-2249.2001.01635.x. PMC 1906187. PMID 11703362.
  • Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, Eigenstetter G, Zobywalski C, Müller-Weihrich S, Graubner U, Schmid I, Sackerer D, Späth M, Goetz C, Prantl F, Asmuss HP, Bise K, Mautner J (August 2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
  • Pallasch CP, Struss AK, Munnia A, König J, Steudel WI, Fischer U, Meese E (November 2005). "Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival". Int. J. Cancer. 117 (3): 456–9. doi:10.1002/ijc.20929. PMID 15906353. S2CID 32083805.
  • Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G (August 2012). "PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53". Nat. Struct. Mol. Biol. 19 (9): 916–24. doi:10.1038/nsmb.2353. PMC 3454513. PMID 22864287.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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