PHKG2

PHKG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y7J
Identifiers
Aliases	PHKG2, GSD9C, phosphorylase kinase catalytic subunit gamma 2
External IDs	OMIM: 172471; MGI: 1916211; HomoloGene: 47915; GeneCards: PHKG2; OMA:PHKG2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,748,293 bp[1] End 30,761,176 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,172,512 bp[2] End 127,182,479 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver anterior pituitary right uterine tube right lobe of thyroid gland left lobe of thyroid gland body of stomach monocyte minor salivary glands skin of abdomen left uterine tube Top expressed in seminiferous tubule spermatid spermatocyte superior frontal gyrus facial motor nucleus cerebellar cortex thymus anterior horn of spinal cord lip proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function phosphorylase kinase activity transferase activity nucleotide binding protein kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity enzyme binding ATP binding protein binding calmodulin-dependent protein kinase activity Cellular component phosphorylase kinase complex cytosol cellular component Biological process phosphorylation generation of precursor metabolites and energy protein phosphorylation glycogen biosynthetic process positive regulation of glycogen catabolic process glycogen metabolic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction carbohydrate metabolic process glycogen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5261 68961 Ensembl ENSG00000156873 ENSMUSG00000030815 UniProt P15735 Q9DB30 RefSeq (mRNA) NM_001172432 NM_000294 NM_026888 NM_001360741 RefSeq (protein) NP_000285 NP_001165903 NP_081164 NP_001347670 Location (UCSC) Chr 16: 30.75 – 30.76 Mb Chr 7: 127.17 – 127.18 Mb PubMed search [3] [4]
Wikidata
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Phosphorylase b kinase gamma catalytic chain, testis/liver isoform is an enzyme that in humans is encoded by the PHKG2 gene.^[5][6][7]

The PHKG2 gene provides instructions for making one piece, the gamma subunit, of the phosphorylase b kinase enzyme. This enzyme is made up of 16 subunits, four each of the alpha, beta, gamma, and delta subunits. (Each subunit is produced from a different gene.) The gamma subunit performs the function of phosphorylase b kinase enzyme, and the other subunits help regulate its activity. This enzyme is found in various tissues, although it is most abundant in the liver and muscles. One version of the enzyme is found in liver cells and another in muscle cells. The gamma-2 subunit produced from the PHKG2 gene is part of the enzyme found in the liver.^[8]

Phosphorylase b kinase plays an important role in providing energy for cells. The main source of cellular energy is a simple sugar called glucose. Glucose is stored in muscle and liver cells in a form called glycogen. Glycogen can be broken down rapidly when glucose is needed, for instance to maintain normal levels of glucose in the blood between meals. Phosphorylase b kinase turns on (activates) another enzyme called glycogen phosphorylase b by converting it to the more active form, glycogen phosphorylase a. When active, this enzyme breaks down glycogen.^[8]

References

Further reading

External links

• GeneReviews/NCBI/NIH/UW entry on Phosphorylase Kinase Deficiency, Glycogen Storage Disease Type IX

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