Protein-coding gene in the species Homo sapiens
| AQP9 |
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| Identifiers |
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| Aliases | AQP9, AQP-9, HsT17287, SSC1, T17287, aquaporin 9 |
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| External IDs | OMIM: 602914; MGI: 1891066; HomoloGene: 41405; GeneCards: AQP9; OMA:AQP9 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 15 (human)[1] |
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| | Band | 15q21.3 | Start | 58,138,169 bp[1] |
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| End | 58,185,911 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 9 (mouse)[2] |
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| | Band | 9|9 D | Start | 71,017,941 bp[2] |
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| End | 71,075,964 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - blood
- monocyte
- right lobe of liver
- periodontal fiber
- granulocyte
- caput epididymis
- germinal epithelium
- corpus epididymis
- bone marrow
- right lung
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| | Top expressed in | - left lobe of liver
- spermatocyte
- granulocyte
- spermatid
- zygote
- secondary oocyte
- seminiferous tubule
- primary oocyte
- blood
- blastocyst
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - porin activity
- carboxylic acid transmembrane transporter activity
- polyol transmembrane transporter activity
- water transmembrane transporter activity
- purine nucleobase transmembrane transporter activity
- pyrimidine nucleobase transmembrane transporter activity
- amine transmembrane transporter activity
- water channel activity
- urea channel activity
- glycerol channel activity
- channel activity
- urea transmembrane transporter activity
| | Cellular component | - integral component of membrane
- intracellular membrane-bounded organelle
- membrane
- plasma membrane
- integral component of plasma membrane
- basolateral plasma membrane
| | Biological process | - canalicular bile acid transport
- excretion
- water transport
- amine transport
- response to organic substance
- water homeostasis
- response to osmotic stress
- polyol transport
- carboxylic acid transport
- immune response
- pyrimidine nucleobase transport
- response to mercury ion
- glycerol transport
- cellular response to cAMP
- purine nucleobase transport
- carboxylic acid transmembrane transport
- purine nucleobase transmembrane transport
- pyrimidine-containing compound transmembrane transport
- transmembrane transport
- urea transmembrane transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_020980
NM_001320635
NM_001320636 |
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| RefSeq (protein) | |
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NP_001307564
NP_001307565
NP_066190 |
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| Location (UCSC) | Chr 15: 58.14 – 58.19 Mb | Chr 9: 71.02 – 71.08 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.[5]
The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a wide variety of noncharged solutes. AQP-9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin-9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103569 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032204 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: AQP9 aquaporin 9".
Further reading
- Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol". Biochem. Biophys. Res. Commun. 244 (1): 268–74. doi:10.1006/bbrc.1998.8252. PMID 9514918.
- Tsukaguchi H, Shayakul C, Berger UV, et al. (1998). "Molecular characterization of a broad selectivity neutral solute channel". J. Biol. Chem. 273 (38): 24737–43. doi:10.1074/jbc.273.38.24737. PMID 9733774.
- Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (1999). "Functional and molecular characterization of the human neutral solute channel aquaporin-9". Am. J. Physiol. 277 (5 Pt 2): F685–96. doi:10.1152/ajprenal.1999.277.5.F685. PMID 10564231. S2CID 4516233.
- Pastor-Soler N, Bagnis C, Sabolic I, et al. (2001). "Aquaporin 9 expression along the male reproductive tract". Biol. Reprod. 65 (2): 384–93. doi:10.1095/biolreprod65.2.384. PMID 11466204.
- Damiano A, Zotta E, Goldstein J, et al. (2001). "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta". Placenta. 22 (8–9): 776–81. doi:10.1053/plac.2001.0717. PMID 11597198.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Okada S, Misaka T, Matsumoto I, et al. (2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1–3): 157–62. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500. S2CID 20184558.
- Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004). "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9". Biochem. Biophys. Res. Commun. 322 (3): 836–41. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wang S, Chen J, Beall M, et al. (2005). "Expression of aquaporin 9 in human chorioamniotic membranes and placenta". Am. J. Obstet. Gynecol. 191 (6): 2160–7. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.
- Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Loitto VM, Huang C, Sigal YJ, Jacobson K (2007). "Filopodia are induced by aquaporin-9 expression". Exp. Cell Res. 313 (7): 1295–306. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.
- Warth A, Mittelbronn M, Hülper P, et al. (2007). "Expression of the water channel protein aquaporin-9 in malignant brain tumors". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633. S2CID 24070875.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
