CD302

Protein-coding gene in the species Homo sapiens
CD302
Identifiers
AliasesCD302, BIMLEC, CLEC13A, DCL-1, DCL1, CD302 molecule
External IDsOMIM: 612246; MGI: 1913455; HomoloGene: 8919; GeneCards: CD302; OMA:CD302 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CD302
Genomic location for CD302
Band2q24.2Start159,768,628 bp[1]
End159,798,255 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for CD302
Genomic location for CD302
Band2|2 C1.1Start60,082,337 bp[2]
End60,114,832 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • monocyte

  • right lung

  • liver

  • synovial joint

  • trabecular bone

  • synovial membrane

  • right lobe of liver

  • Achilles tendon

  • superficial temporal artery
Top expressed in
  • left lobe of liver

  • white adipose tissue

  • calvaria

  • stroma of bone marrow

  • right kidney

  • tunica adventitia of aorta

  • right lung lobe

  • mesenteric lymph nodes

  • carotid body

  • skin of external ear
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • carbohydrate binding
  • transmembrane signaling receptor activity
Cellular component
  • filopodium
  • cytoplasm
  • integral component of membrane
  • microvillus
  • cell projection
  • cell cortex
  • membrane
  • integral component of plasma membrane
Biological process
  • phagocytosis
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9936

66205

Ensembl

ENSG00000241399

ENSMUSG00000060703

UniProt

Q8IX05

Q9DCG2

RefSeq (mRNA)

NM_014880
NM_001198763
NM_001198764

NM_001290660
NM_025422

RefSeq (protein)

NP_001185692
NP_001185693
NP_055695

NP_001277589
NP_079698

Location (UCSC)Chr 2: 159.77 – 159.8 MbChr 2: 60.08 – 60.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.[5][6]

Function

CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241399 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060703 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  6. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  7. ^ Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN (November 2007). "The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration". J. Immunol. 179 (9): 6052–63. doi:10.4049/jimmunol.179.9.6052. PMID 17947679.

External links

Further reading

  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yang S, Noble CG, Yang D (2009). "Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level". Biochemistry. 48 (19): 4040–9. doi:10.1021/bi9000936. PMID 19317456.
  • Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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