CEACAM1

CEACAM1
Available structures PDB Ortholog search: P13688%20or%20M0R2K4 PDBe P13688,M0R2K4 RCSB List of PDB id codes 2GK2, 4QXW, 5DZL, 4WHD
Identifiers
Aliases	CEACAM1, BGP, BGP1, BGPI, carcinoembryonic antigen related cell adhesion molecule 1, CEA cell adhesion molecule 1
External IDs	OMIM: 109770; MGI: 1347246; HomoloGene: 128630; GeneCards: CEACAM1; OMA:CEACAM1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 42,507,304 bp[1] End 42,561,234 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 13.87 cM Start 25,215,467 bp[2] End 25,239,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum minor salivary glands jejunal mucosa duodenum bone marrow bone marrow cells appendix oral cavity parotid gland right lobe of liver Top expressed in spermatid proximal tubule seminiferous tubule left colon secondary oocyte lens major salivary gland parotid gland duodenum intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinase binding protein homodimerization activity protein phosphatase binding protein tyrosine kinase binding filamin binding bile acid transmembrane transporter activity protein dimerization activity actin binding calmodulin binding molecular function identical protein binding Cellular component membrane integral component of membrane extracellular region integral component of plasma membrane extracellular exosome T cell receptor complex cell-cell junction cell surface plasma membrane adherens junction basal plasma membrane apical plasma membrane lateral plasma membrane cell junction transport vesicle membrane cytoplasmic vesicle microvillus membrane specific granule membrane cell projection tertiary granule membrane Biological process integrin-mediated signaling pathway cell migration angiogenesis leukocyte migration insulin catabolic process positive regulation of vasculogenesis cellular response to insulin stimulus negative regulation of cytotoxic T cell degranulation regulation of ERK1 and ERK2 cascade regulation of homophilic cell adhesion negative regulation of vascular permeability regulation of endothelial cell migration negative regulation of interleukin-1 production homophilic cell adhesion via plasma membrane adhesion molecules granulocyte colony-stimulating factor signaling pathway wound healing, spreading of cells negative regulation of hepatocyte proliferation negative regulation of granulocyte differentiation negative regulation of platelet aggregation blood vessel development negative regulation of lipid biosynthetic process bile acid and bile salt transport regulation of blood vessel remodeling negative regulation of T cell receptor signaling pathway negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target regulation of cell growth insulin receptor internalization negative regulation of T cell mediated cytotoxicity regulation of sprouting angiogenesis negative regulation of protein kinase activity negative regulation of fatty acid biosynthetic process regulation of cell migration regulation of phosphatidylinositol 3-kinase signaling common myeloid progenitor cell proliferation regulation of epidermal growth factor receptor signaling pathway regulation of endothelial cell differentiation cell adhesion neutrophil degranulation cell-cell adhesion via plasma-membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 634 26367 Ensembl ENSG00000079385 ENSMUSG00000054385 UniProt Q3KRG8 Q925P2 RefSeq (mRNA) NM_001024912 NM_001184813 NM_001184815 NM_001184816 NM_001205344 NM_001712 NM_001113368 NM_001113369 NM_007543 RefSeq (protein) NP_001020083.1 NP_001020083 NP_001171742 NP_001171744 NP_001171745 NP_001192273 NP_001703 NP_001106839 NP_001106840 NP_031569 Location (UCSC) Chr 19: 42.51 – 42.56 Mb Chr 7: 25.22 – 25.24 Mb PubMed search [3] [4]
Wikidata
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Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.^[5]

Function

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.^[5]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.^[6]

Interactions

CEACAM1 has been shown to interact with PTPN11^[7] and Annexin A2.^[8]

See also

• Carcinoembryonic antigen
• Cluster of differentiation

References

Further reading

External links

• CEACAM1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CEACAM1 genome location and CEACAM1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.