IL22RA1
Protein-coding gene in the species Homo sapiens
| IL22RA1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | IL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605457; MGI: 2663588; HomoloGene: 10943; GeneCards: IL22RA1; OMA:IL22RA1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.[5]
Function
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142677 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037157 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Interleukin 22 receptor, alpha 1".
Further reading
- Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I (September 2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–92. doi:10.1016/j.febslet.2008.07.046. PMID 18675809. S2CID 20952148.
- Jones BC, Logsdon NJ, Walter MR (September 2008). "Structure of IL-22 bound to its high-affinity IL-22R1 chain". Structure. 16 (9): 1333–44. doi:10.1016/j.str.2008.06.005. PMC 2637415. PMID 18599299.
- de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I (April 2009). "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters. 583 (7): 1072–7. doi:10.1016/j.febslet.2009.03.006. PMID 19285080.
- Dumoutier L, de Meester C, Tavernier J, Renauld JC (September 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain". The Journal of Biological Chemistry. 284 (39): 26377–84. doi:10.1074/jbc.M109.007955. PMC 2785325. PMID 19632985.
- Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA (October 2008). "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–83. doi:10.1016/j.jmb.2008.07.046. PMID 18675824.
- Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C (August 2010). "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation". Journal of Molecular Cell Biology. 2 (4): 223–30. doi:10.1093/jmcb/mjq017. PMC 2948820. PMID 20671117.
- Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S (January 2001). "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes". The Journal of Biological Chemistry. 276 (4): 2725–32. doi:10.1074/jbc.M007837200. PMID 11035029.
- Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q (December 2012). "Th17-associated cytokines promote human airway smooth muscle cell proliferation". FASEB Journal. 26 (12): 5152–60. doi:10.1096/fj.12-208033. PMID 22898922. S2CID 205369384.
- Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y (March 2008). "Interleukin 22 receptor 1 expression in pancreas islets". Pancreas. 36 (2): 197–9. doi:10.1097/MPA.0b013e3181594258. PMID 18376313. S2CID 26713011.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(GPCRs)
| CC | |
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| CXC | |
| Other |
| 1-10 | |
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| 11-20 | |
| 21-27 |
| Type I |
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| Type II |
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