CCBP2

Protein-coding gene in the species Homo sapiens
ACKR2
Identifiers
AliasesACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDsOMIM: 602648; MGI: 1891697; HomoloGene: 992; GeneCards: ACKR2; OMA:ACKR2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ACKR2
Genomic location for ACKR2
Band3p22.1Start42,804,752 bp[1]
End42,887,974 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ACKR2
Genomic location for ACKR2
Band9|9 F4Start121,727,421 bp[2]
End121,740,140 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • right lobe of liver

  • testicle

  • gonad

  • tibial nerve

  • sural nerve

  • subcutaneous adipose tissue

  • tibialis anterior muscle

  • mucosa of transverse colon

  • left coronary artery
Top expressed in
  • right lung lobe

  • ankle

  • left lung lobe

  • embryo

  • skin of external ear

  • carotid body

  • decidua

  • gastrula

  • submandibular gland

  • mesenteric lymph nodes
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • chemokine receptor activity
  • C-C chemokine binding
  • G protein-coupled receptor activity
  • scavenger receptor activity
  • C-C chemokine receptor activity
  • chemokine binding
Cellular component
  • integral component of membrane
  • early endosome
  • recycling endosome
  • membrane
  • actin filament
  • endosome
  • plasma membrane
  • integral component of plasma membrane
  • nucleoplasm
  • cytosol
  • nuclear membrane
  • intracellular membrane-bounded organelle
  • external side of plasma membrane
Biological process
  • signal transduction
  • multicellular organism development
  • inflammatory response
  • immune response
  • chemokine-mediated signaling pathway
  • G protein-coupled receptor signaling pathway
  • chemotaxis
  • receptor-mediated endocytosis
  • positive regulation of cytosolic calcium ion concentration
  • calcium-mediated signaling
  • cell chemotaxis
  • vesicle-mediated transport
  • endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1238

59289

Ensembl

ENSG00000144648

ENSMUSG00000044534

UniProt

O00590

O08707

RefSeq (mRNA)

NM_001296

NM_001276719
NM_021609

RefSeq (protein)

NP_001287

NP_001263648
NP_067622

Location (UCSC)Chr 3: 42.8 – 42.89 MbChr 9: 121.73 – 121.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[5][6][7]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144648 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044534 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
  6. ^ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
  7. ^ a b "Entrez Gene: CCBP2 chemokine binding protein 2".

Further reading

  • Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ (1997). "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5". J. Biol. Chem. 272 (19): 12495–504. doi:10.1074/jbc.272.19.12495. PMID 9139699.
  • Nibbs RJ, Yang J, Landau NR, et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity". J. Biol. Chem. 274 (25): 17478–83. doi:10.1074/jbc.274.25.17478. PMID 10364178.
  • Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689. S2CID 1178132.
  • Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
  • Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
  • Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
  • Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
  • Nibbs RJ, Kriehuber E, Ponath PD, et al. (2001). "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors". Am. J. Pathol. 158 (3): 867–77. doi:10.1016/s0002-9440(10)64035-7. PMC 1850343. PMID 11238036.
  • Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
  • Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking". Blood. 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fra AM, Locati M, Otero K, et al. (2003). "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6". J. Immunol. 170 (5): 2279–82. doi:10.4049/jimmunol.170.5.2279. PMID 12594248.
  • Kunkel EJ, Kim CH, Lazarus NH, et al. (2003). "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells". J. Clin. Invest. 111 (7): 1001–10. doi:10.1172/JCI17244. PMC 152588. PMID 12671049.
  • Galliera E, Jala VR, Trent JO, et al. (2004). "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6". J. Biol. Chem. 279 (24): 25590–7. doi:10.1074/jbc.M400363200. PMID 15084596.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Neil SJ, Aasa-Chapman MM, Clapham PR, et al. (2005). "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes". J. Virol. 79 (15): 9618–24. doi:10.1128/JVI.79.15.9618-9624.2005. PMC 1181543. PMID 16014924.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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