Analogni pirimidini
Analogni pirimidini su antimetaboliti, koji imitiraju strukturu metaboličkih pirimidina.
Primeri
- 5-flourouracil[1] (5FU) koji inhibira timidilat sintazu.[2]
- Floksuridin (FUDR)
- Citozin arabinozid (Citarabin)
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Pirimidin -
Fluorouracil -
Floksuridin -
Gemcitabin
Reference
- ↑ Huhtala A, Rönkkö S, Teräsvirta M, et al. (May 2009). „The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant”. Invest. Ophthalmol. Vis. Sci. 50 (5): 2216–23. DOI:10.1167/iovs.08-3016. PMID 19136700.
- ↑ Xi Y, Formentini A, Nakajima G, Kornmann M, Ju J (January 2008). „Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer”. Oncol. Rep. 19 (1): 257–62. PMID 18097604.
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Intracelularni hemoterapijski lekovi/Antineoplastični lekovi (L01)
(M faza)
Blokiranje formiranja microtubule | |
|---|---|
Blokiranje rasformiranja microtubule |
DNK replikacije
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FI (Tipifarnib) • CDK inhibitori (Alvocidib, Seliciklib) • PrI (Bortezomib) • PhI (Anagrelid) • IMPDI (Tiazofurin) • LI (Masoprokol) • PARP inhibitor (Olaparib) • HDAC (Vorinostat, Romidepsin) | |
Receptorski antagonisti | |
Drugi/negrupisani | Amsakrin • Trabektedin • retinoidi (Alitretinoin, Tretinoin) • Arsen trioksid • asparaginski iscrpljivači (Asparaginaza/Pegaspargaza) • Celekoksib • Demekolcin • Elesklomol • Elsamitrucin • Etoglucid • Lonidamin • Lukanton • Mitoguazon • Mitotan • Oblimersen • mTOR inhibitori (Everolimus, Temsirolimus) |
