Alfa-1D adrenergički receptor

Adrenergički alfa-1D receptor

Identifikatori

ADRA1D; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2

Vanjski ID

OMIM: 104219 MGI: 106673 HomoloGene: 551 IUPHAR: α_1D-adrenoceptor GeneCards: ADRA1D Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost adrenoceptora • aktivnost alfa1-adrenergičkog receptora
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• DNK metabolički proces • prenos signala • signalni put G-protein spregnutog receptora • G-protein signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glanikom • interćelijska signalizacija • razvoj multićelijskog organizma • ćelijska proliferacija • pozitivna regulacija ćelijske proliferacije

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

146

11550

Ensembl

ENSG00000171873

ENSMUSG00000027335

UniProt

P25100

P97714

RefSeq (mRNA)

NM_000678

NM_013460

RefSeq (protein)

NP_000669

NP_038488

Lokacija (UCSC)

Chr 20:
4.15 - 4.18 Mb

Chr 2:
131.24 - 131.25 Mb

PubMed pretraga

[1]

[2]

Alfa-1D adrenergički receptor (α_1D adrenoreceptor, ADRA1D) je alfa-1 adrenergički receptor, koji je kodiran humanim ADRA1D genom.^[1]

Receptor

Postoje 3 tipa alfa-1 adrenergičkog receptora: alfa-1A, -1B i -1D, svi od kojih prenose signal kroz Gq/11 familiju G-proteina. Različiti podtipovi pokazuju različite oblike aktivacije. Oni aktiviraju mitogene response i regulišu rast i proliferaciju mnogih ćelija.

Gene

Ovaj gen kodira alfa-1D-adrenergički receptor. On je sličan genu alfa-1B adrenergičkog receptora, i se sastoji od 2 iRNK eksona i jednog velikog introna sa najmanje 20 kb.^[1]

Vidi još

Adrenergički receptor

Literatura

^ ^а ^б „Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor”.

Dodatna literatura

Schwinn DA, Lomasney JW (1992). „Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.”. Eur. J. Pharmacol. 227 (4): 433—6. PMID 1359975. doi:10.1016/0922-4106(92)90162-O.
Bruno JF, Whittaker J, Song JF, Berelowitz M (1991). „Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.”. Biochem. Biophys. Res. Commun. 179 (3): 1485—90. PMID 1656955. doi:10.1016/0006-291X(91)91740-4.
TA, Esbenshade; Hirasawa A; Tsujimoto G (1995). „Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.”. Mol. Pharmacol. 47 (5): 977—85. PMID 7746284.
DA, Schwinn; Johnston GI; Page SO (1995). „Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.”. J. Pharmacol. Exp. Ther. 272 (1): 134—42. PMID 7815325.
DH, Weinberg; Trivedi P; Tan CP (1994). „Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.”. Biochem. Biophys. Res. Commun. 201 (3): 1296—304. PMID 8024574. doi:10.1006/bbrc.1994.1845.
SK, Loftus; Shiang R; Warrington JA (1994). „Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.”. Cytogenet. Cell Genet. 67 (2): 69—74. PMID 8039425. doi:10.1159/000133802.
Yang-Feng TL, Han H, Lomasney JW, Caron MG (1994). „Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13.”. Cytogenet. Cell Genet. 66 (3): 170—1. PMID 8125015. doi:10.1159/000133693.
C, Forray; Bard JA; Wetzel JM (1994). „The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.”. Mol. Pharmacol. 45 (4): 703—8. PMID 8183249.
KP, Minneman; Lee D; Zhong H (2000). „Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.”. J. Neurochem. 74 (6): 2392—400. PMID 10820200. doi:10.1046/j.1471-4159.2000.0742392.x.
Keffel S, Alexandrov A, Goepel M, Michel MC (2000). „alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.”. Biochem. Biophys. Res. Commun. 272 (3): 906—11. PMID 10860850. doi:10.1006/bbrc.2000.2850.
Kyprianou N, Benning CM (2000). „Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.”. Cancer Res. 60 (16): 4550—5. PMID 10969806.
P, Deloukas; Matthews LH; Ashurst J (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature. 414 (6866): 865—71. PMID 11780052. doi:10.1038/414865a.
K, Shibata; Katsuma S; Koshimizu T (2003). „alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.”. J. Biol. Chem. 278 (1): 672—8. PMID 12409310. doi:10.1074/jbc.M201375200.
Pupo AS, Minneman KP (2004). „Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.”. J. Recept. Signal Transduct. Res. 23 (2-3): 185—95. PMID 14626446. doi:10.1081/RRS-120025200.
C, Hague; Uberti MA; Chen Z (2004). „Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.”. J. Biol. Chem. 279 (15): 15541—9. PMID 14736874. doi:10.1074/jbc.M314014200.
Gonzalez-Cabrera PJ; Shi T; Yun J (2004). „Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.”. Endocrinology. 145 (11): 5157—67. PMID 15297446. doi:10.1210/en.2004-0728.
T, Zhang; Xu Q; Chen FR (2005). „Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.”. Acta Pharmacol. Sin. 25 (11): 1471—8. PMID 15525470.
S, Sigala; Dellabella M; Milanese G (2005). „Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter.”. Neurourol. Urodyn. 24 (2): 142—8. PMID 15690361. doi:10.1002/nau.20097.
Chen Z, Hague C, Hall RA, Minneman KP (2006). „Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.”. J. Biol. Chem. 281 (18): 12414—20. PMID 16533813. doi:10.1074/jbc.M508651200.
GA, Michelotti; Brinkley DM; Morris DP (2007). „Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.”. FASEB J. 21 (9): 1979—93. PMC 2279228 . PMID 17384146. doi:10.1096/fj.06-7118com.

Spoljašnje veze

„α_1D”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 04. 03. 2016. г.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)