GABBR2

Receptor 2 gama-aminobuterne kiseline B
Identifikatori
Simboli GABBR2; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
Vanjski ID OMIM: 607340 MGI: 2386030 HomoloGene: 55902 IUPHAR: GABAB2 GeneCards: GABBR2 Gene
Ontologija gena
Molekularna funkcija • aktivnost prenosnika signala
• receptorska aktivnost
• aktivnost G-protein spregnutog GABA receptora
Celularna komponenta • citoplazma
• ćelijska membrana
• integralno sa ćelijskom membranom
• ćelijski spoj
• neuronska projekcija
• sinapsa
• postsinaptička membrana
Biološki proces • signalni put G-protein spregnutog receptora
• negativna regulacija aktivnosti adenilat ciklaze
• signalni put gama-aminobuterne kiseline
• sinaptička transmisija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 9568 242425
Ensembl ENSG00000136928 ENSMUSG00000039809
UniProt O75899 Q80T41
RefSeq (mRNA) NM_005458.7 NM_001081141.1
RefSeq (protein) NP_005449.5 NP_001074610.1
Lokacija (UCSC) Chr 9:
101.05 - 101.47 Mb		 Chr 4:
46.68 - 47 Mb
PubMed pretraga [1] [2]

Receptor 2 gama-aminobuterne kiseline B (GABAB1) je podjedinica G protein spregnutog receptora koja je kod ljudi kodirana GABBR2 genom.[1]

B-tip receptora za neurotransmiter GABA (gama-aminobuterna kiselina) inhibira neuronsku aktivnost putem G protein spregnutog sistema sekundarnih glasnika, koji reguliše oslobađanje neurotransmiter, aktivnost jonskih kanala i adenilil ciklaze.[1]

Interakcije

Poznato je da GABBR2 formira interakcije sa GABBR1.[2]

Vidi još

  • GABAB receptor

Reference

  1. ^ а б „Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2”. 
  2. ^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1998). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature. ENGLAND. 396 (6712): 679—82. ISSN 0028-0836. PMID 9872316. doi:10.1038/25354. 

Literatura

  • White JH; Wise A; Main MJ; et al. (1999). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature. 396 (6712): 679—82. PMID 9872316. doi:10.1038/25354. 
  • Ng GY; Clark J; Coulombe N; et al. (1999). „Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity”. J. Biol. Chem. 274 (12): 7607—10. PMID 10075644. doi:10.1074/jbc.274.12.7607. 
  • Ng GY; McDonald T; Bonnert T; et al. (1999). „Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9”. Genomics. 56 (3): 288—95. PMID 10087195. doi:10.1006/geno.1998.5706. 
  • Martin SC, Russek SJ, Farb DH (1999). „Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1”. Mol. Cell. Neurosci. 13 (3): 180—91. PMID 10328880. doi:10.1006/mcne.1999.0741. 
  • Clark JA, Mezey E, Lam AS, Bonner TI (2000). „Distribution of the GABA(B) receptor subunit gb2 in rat CNS”. Brain Res. 860 (1–2): 41—52. PMID 10727622. doi:10.1016/S0006-8993(00)01958-2. 
  • Sullivan R; Chateauneuf A; Coulombe N; et al. (2000). „Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor”. J. Pharmacol. Exp. Ther. 293 (2): 460—7. PMID 10773016. 
  • White JH; McIllhinney RA; Wise A; et al. (2001). „The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”. Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967—72. PMC 17684 Слободан приступ. PMID 11087824. doi:10.1073/pnas.240452197. 
  • Kitano J; Kimura K; Yamazaki Y; et al. (2002). „Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins”. J. Neurosci. 22 (4): 1280—9. PMID 11850456. 
  • Salim K; Fenton T; Bacha J; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482—5. PMID 11854302. doi:10.1074/jbc.M201539200. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Furtinger S; Pirker S; Czech T; et al. (2004). „Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy”. Neurosci. Lett. 352 (2): 141—5. PMID 14625043. doi:10.1016/j.neulet.2003.08.046. 
  • Waldvogel HJ; Billinton A; White JH; et al. (2004). „Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits”. J. Comp. Neurol. 470 (4): 339—56. PMID 14961561. doi:10.1002/cne.20005. 
  • Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). „Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking”. J. Biol. Chem. 279 (18): 18840—50. PMID 14966130. doi:10.1074/jbc.M313470200. 
  • Uezono Y; Kaibara M; Hayashi H; et al. (2004). „Characterization of GABAB receptor in the human colon”. J. Pharmacol. Sci. 94 (2): 211—3. PMID 14978362. doi:10.1254/jphs.94.211. 
  • Humphray SJ; Oliver K; Hunt AR; et al. (2004). „DNA sequence and analysis of human chromosome 9”. Nature. 429 (6990): 369—74. PMC 2734081 Слободан приступ. PMID 15164053. doi:10.1038/nature02465. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Hlavackova V; Goudet C; Kniazeff J; et al. (2005). „Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR”. EMBO J. 24 (3): 499—509. PMC 548662 Слободан приступ. PMID 15660124. doi:10.1038/sj.emboj.7600557. 
  • DeGiorgis JA; Jaffe H; Moreira JE; et al. (2005). „Phosphoproteomic analysis of synaptosomes from human cerebral cortex”. J. Proteome Res. 4 (2): 306—15. PMID 15822905. doi:10.1021/pr0498436. 
  • Rual JF; Venkatesan K; Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209. 
  • Osawa Y; Xu D; Sternberg D; et al. (2006). „Functional expression of the GABAB receptor in human airway smooth muscle”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923—31. PMID 16829628. doi:10.1152/ajplung.00185.2006. 

Spoljašnje veze

  • „GABAB Receptors: GABAB2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 08. 08. 2014. г. 
  • п
  • р
  • у
Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni