P2RY4

Pirimidinski receptor P2Y, G-protein spregnuti, 4

Identifikatori

P2RY4; NRU; P2P; P2Y4; UNR

Vanjski ID

OMIM: 300038 MGI: 1926594 HomoloGene: 20568 IUPHAR: P2Y₄ GeneCards: P2RY4 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost UTP-aktiviranog nukleotidnog receptora
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • G-proteinska signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C) • elevacija koncentracije citosolnih jona kalcijuma • transepitelni hloridni transport

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5030

57385

Ensembl

ENSG00000186912

ENSMUSG00000044359

UniProt

P51582

Q0VBT7

RefSeq (mRNA)

NM_002565

NM_020621

RefSeq (protein)

NP_002556

NP_065646

Lokacija (UCSC)

Chr X:
69.39 - 69.4 Mb

Chr X:
96.79 - 96.8 Mb

PubMed pretraga

[1]

[2]

P2Y purinoceptor 4 je protein koji je kod ljudi kodiran P2RY4 genom.^[1]^[2]

Proizvod ovog gena, P2Y₄, pripada familiji G-protein spregnutih receptora. Ova grupa sadrži više tipova receptora sa različitom farmakološkim selektivnostima za razne adenozinske i uridinske nukleotide, koje se preklapaju u nekim slučajevima. Ovaj receptor je responsivan na uridinske nukleotide, posebno na ATP, i nije responsivan na ADP.^[2]

Vidi još

P2Y receptor

Literatura

^ Communi D, Pirotton S, Parmentier M, Boeynaems JM (1996). „Cloning and functional expression of a human uridine nucleotide receptor”. J Biol Chem. 270 (52): 30849—52. PMID 8537336. doi:10.1074/jbc.270.52.30849.
^ ^а ^б „Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4”.

Dodatna literatura

Nguyen T; Erb L; Weisman GA; et al. (1996). „Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene.”. J. Biol. Chem. 270 (52): 30845—8. PMID 8537335. doi:10.1074/jbc.270.52.30845. CS1 одржавање: Експлицитна употреба et al. (веза)
Stam NJ, Klomp J, Van de Heuvel N, Olijve W (1996). „Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor.”. FEBS Lett. 384 (3): 260—4. PMID 8617367. doi:10.1016/0014-5793(96)00321-3.
Nicholas RA; Watt WC; Lazarowski ER; et al. (1996). „Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.”. Mol. Pharmacol. 50 (2): 224—9. PMID 8700127. CS1 одржавање: Експлицитна употреба et al. (веза)
Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297—302. PMID 9268704. doi:10.1006/bbrc.1997.7135.
Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). „Distribution of P2Y receptor subtypes on haematopoietic cells.”. Br. J. Pharmacol. 123 (5): 789—94. PMC 1565225 . PMID 9535005. doi:10.1038/sj.bjp.0701665.
Brinson AE, Harden TK (2001). „Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.”. J. Biol. Chem. 276 (15): 11939—48. PMID 11114308. doi:10.1074/jbc.M009909200.
Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B (2001). „Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor.”. Eur. J. Pharmacol. 416 (3): 197—202. PMID 11290369. doi:10.1016/S0014-2999(01)00875-5.
Moore DJ; Chambers JK; Wahlin JP; et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID 11690642. CS1 одржавање: Експлицитна употреба et al. (веза)
Idzko M; Dichmann S; Ferrari D; et al. (2002). „Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.”. Blood. 100 (3): 925—32. PMID 12130504. doi:10.1182/blood.V100.3.925. CS1 одржавање: Експлицитна употреба et al. (веза)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). „Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.”. J. Invest. Dermatol. 120 (3): 440—7. PMID 12603858. doi:10.1046/j.1523-1747.2003.12050.x.
Kim SG; Soltysiak KA; Gao ZG; et al. (2003). „Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.”. Biochem. Pharmacol. 65 (6): 923—31. PMID 12623123. doi:10.1016/S0006-2952(02)01614-3. CS1 одржавање: Експлицитна употреба et al. (веза)
Herold CL, Qi AD, Harden TK, Nicholas RA (2004). „Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.”. J. Biol. Chem. 279 (12): 11456—64. PMC 1821344 . PMID 14670966. doi:10.1074/jbc.M301734200.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Cavaliere F; Nestola V; Amadio S; et al. (2005). „The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.”. Neurobiol. Dis. 18 (1): 100—9. PMID 15649700. doi:10.1016/j.nbd.2004.09.001. CS1 одржавање: Експлицитна употреба et al. (веза)
Ross MT; Grafham DV; Coffey AJ; et al. (2005). „The DNA sequence of the human X chromosome.”. Nature. 434 (7031): 325—37. PMC 2665286 . PMID 15772651. doi:10.1038/nature03440. CS1 одржавање: Експлицитна употреба et al. (веза)

Spoljašnje veze

„P2Y Receptors: P2Y₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)