OPN1SW

Opsin 1 (pigment kupe)

Identifikatori

OPN1SW; BCP; BOP; CBT

Vanjski ID

OMIM: 190900 MGI: 99438 HomoloGene: 1291 GeneCards: OPN1SW Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost fotorecptora plave svetlosti
Celularna komponenta	• fotoreceptorski spoljašnje segment • integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • vizuelna percepcija • fototransdukcija • protein-hromofor veza • respons na stimulus

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

611

12057

Ensembl

ENSG00000128617

ENSMUSG00000058831

UniProt

P03999

P51491

RefSeq (mRNA)

NM_001708

NM_007538

RefSeq (protein)

NP_001699

NP_031564

Lokacija (UCSC)

Chr 7:
128.2 - 128.2 Mb

Chr 6:
29.33 - 29.33 Mb

PubMed pretraga

[1]

[2]

OPN1SW, plavo-senzitivni opsin je protein koji je kod ljudi kodiran OPN1SW genom.^[1]^[2]^[3]

Vidi još

Opsin

Literatura

^ Nathans J, Thomas D, Hogness DS (1986). „Molecular genetics of human color vision: the genes encoding blue, green, and red pigments”. Science. 232 (4747): 193—202. PMID 2937147. doi:10.1126/science.2937147.
^ Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM (1994). „Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32”. Hum Genet. 93 (1): 79—80. PMID 8270261.
^ „Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)”.

Dodatna literatura

Applebury ML, Hargrave PA (1987). „Molecular biology of the visual pigments.”. Vision Res. 26 (12): 1881—95. PMID 3303660. doi:10.1016/0042-6989(86)90115-X.
Swanson WH, Cohen JM (2003). „Color vision.”. Ophthalmology clinics of North America. 16 (2): 179—203. PMID 12809157. doi:10.1016/S0896-1549(03)00004-X.
Weitz CJ, Went LN, Nathans J (1992). „Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment.”. Am. J. Hum. Genet. 51 (2): 444—6. PMC 1682686 . PMID 1386496.
Weitz CJ; Miyake Y; Shinzato K; et al. (1992). „Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.”. Am. J. Hum. Genet. 50 (3): 498—507. PMC 1684278 . PMID 1531728. CS1 одржавање: Експлицитна употреба et al. (веза)
Oprian DD, Asenjo AB, Lee N, Pelletier SL (1992). „Design, chemical synthesis, and expression of genes for the three human color vision pigments.”. Biochemistry. 30 (48): 11367—72. PMID 1742276. doi:10.1021/bi00112a002.
Sarkar G, Sommer SS (1989). „Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity.”. Science. 244 (4902): 331—4. PMID 2565599. doi:10.1126/science.2565599.
Nathans J; Piantanida TP; Eddy RL; et al. (1986). „Molecular genetics of inherited variation in human color vision.”. Science. 232 (4747): 203—10. PMID 3485310. doi:10.1126/science.3485310. CS1 одржавање: Експлицитна употреба et al. (веза)
Shimmin LC, Mai P, Li WH (1997). „Sequences and evolution of human and squirrel monkey blue opsin genes.”. J. Mol. Evol. 44 (4): 378—82. PMID 9089077. doi:10.1007/PL00006157.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423. CS1 одржавање: Експлицитна употреба et al. (веза)
Gunther KL, Neitz J, Neitz M (2006). „A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect.”. Vis. Neurosci. 23 (3-4): 403—9. PMID 16961973. doi:10.1017/S0952523806233169.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)