| HNF1B |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 2DA6, 2H8R | | |
| Ідентифікатори |
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| Символи | HNF1B, FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF-1-beta, HNF1 homeobox B, T2D, ADTKD3, RCAD |
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| Зовнішні ІД | OMIM: 189907 MGI: 98505 HomoloGene: 396 GeneCards: HNF1B |
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| Пов'язані генетичні захворювання |
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| цукровий діабет 2-го типу, endometrial cancer, рак простати[1] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• sequence-specific DNA binding
• protein homodimerization activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001948, GO:0016582 protein binding
• protein heterodimerization activity
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001158 cis-regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0032403 protein-containing complex binding
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| Клітинна компонента | • transcription regulator complex
• нуклеоплазма
• клітинне ядро
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| Біологічний процес | • Сигнальний шлях Notch
• pronephros development
• mesonephric tubule development
• endoderm development
• GO:0009373 regulation of transcription, DNA-templated
• GO:1904578 response to organic cyclic compound
• mesonephric duct development
• endodermal cell fate specification
• розвиток нирки
• mesonephric duct formation
• ureteric bud elongation
• protein-DNA complex assembly
• negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
• hindbrain development
• hepatocyte differentiation
• epithelial cell proliferation
• insulin secretion
• negative regulation of apoptotic process
• GO:1901227 negative regulation of transcription by RNA polymerase II
• response to glucose
• positive regulation of transcription initiation from RNA polymerase II promoter
• nephric duct formation
• circadian regulation of gene expression
• transcription, DNA-templated
• regulation of branch elongation involved in ureteric bud branching
• negative regulation of mesenchymal cell apoptotic process involved in metanephros development
• epithelium development
• nephric duct development
• genitalia development
• pronephric nephron tubule development
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• hepatoblast differentiation
• regulation of Wnt signaling pathway
• GO:1901313 positive regulation of gene expression
• inner cell mass cell differentiation
• embryonic morphogenesis
• kidney morphogenesis
• embryonic digestive tract morphogenesis
• liver development
• regulation of endodermal cell fate specification
• branching morphogenesis of an epithelial tube
• response to carbohydrate
• regulation of pronephros size
• anterior/posterior pattern specification
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• endocrine pancreas development
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• pancreas development
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | ENSG00000276194
ENSG00000275410 |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_000458
NM_001165923
NM_001304286
NM_006481 |
| | NM_001291268
NM_001291269
NM_009330 |
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| RefSeq (білок) | | NP_000449
NP_001159395
NP_001291215
NP_001159395.1 |
| | NP_001278197
NP_001278198
NP_033356 |
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| Локус (UCSC) | Хр. 17: 37.69 – 37.75 Mb | Хр. 11: 83.74 – 83.8 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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