| RORA |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1N83, 1S0X, 4S15 | | |
| Ідентифікатори |
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| Символи | RORA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, RAR related orphan receptor A, IDDECA |
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| Зовнішні ІД | OMIM: 600825 MGI: 104661 HomoloGene: 56594 GeneCards: RORA |
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| Пов'язані генетичні захворювання |
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| шизофренія, бронхіальна астма, депресія клінічна[1] |
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| Реагує на сполуку |
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| холестерол[2] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• sequence-specific DNA binding
• beta-catenin binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• ligand-activated transcription factor activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• zinc ion binding
• transcription factor binding
• зв'язування з іоном металу
• steroid hormone receptor activity
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• core promoter sequence-specific DNA binding
• GO:0001948, GO:0016582 protein binding
• transcription coactivator binding
• transcription corepressor binding
• oxysterol binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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| Клітинна компонента | • нуклеоплазма
• клітинне ядро
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| Біологічний процес | • negative regulation of fat cell differentiation
• nitric oxide biosynthetic process
• GO:0009373 regulation of transcription, DNA-templated
• cGMP metabolic process
• ритмічний процес
• cellular response to sterol
• cellular response to tumor necrosis factor
• cerebellar Purkinje cell differentiation
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• circadian regulation of gene expression
• transcription, DNA-templated
• cerebellar granule cell precursor proliferation
• regulation of steroid metabolic process
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• regulation of smoothened signaling pathway
• muscle cell differentiation
• intracellular receptor signaling pathway
• regulation of glucose metabolic process
• regulation of circadian rhythm
• Ангіогенез
• cellular response to interleukin-1
• xenobiotic metabolic process
• positive regulation of circadian rhythm
• positive regulation of vascular endothelial growth factor production
• T-helper 17 cell differentiation
• transcription initiation from RNA polymerase II promoter
• negative regulation of inflammatory response
• cellular response to hypoxia
• triglyceride homeostasis
• regulation of macrophage activation
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• steroid hormone mediated signaling pathway
• циркадний ритм
• cytokine-mediated signaling pathway
• cholesterol homeostasis
• multicellular organism development
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_002943
NM_134260
NM_134261
NM_134262 |
| | NM_013646
NM_001289916
NM_001289917 |
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| RefSeq (білок) | | NP_002934
NP_599022
NP_599023
NP_599024 |
| | NP_001276845
NP_001276846
NP_038674 |
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| Локус (UCSC) | Хр. 15: 60.49 – 61.23 Mb | Хр. 9: 68.56 – 69.3 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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