| NR1H2 |
|---|
 |
| Наявні структури |
|---|
| PDB | Пошук ортологів: PDBe RCSB |
|---|
| Список кодів PDB | | 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA | | |
| Ідентифікатори |
|---|
| Символи | NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2 |
|---|
| Зовнішні ІД | OMIM: 600380 MGI: 1352463 HomoloGene: 21397 GeneCards: NR1H2 |
|---|
| |
| Реагує на сполуку |
|---|
| (25R)-cholest-5-ene-3β,26-diol, desmosterol[1] |
| Онтологія гена |
|---|
| Молекулярна функція | • DNA binding
• sequence-specific DNA binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• ATPase binding
• zinc ion binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• зв'язування з іоном металу
• retinoid X receptor binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• steroid hormone receptor activity
• apolipoprotein A-I receptor binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• GO:0001948, GO:0016582 protein binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0000975 transcription cis-regulatory region binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• transcription factor binding
• nuclear receptor coactivator activity
• signaling receptor activity
|
|---|
| Клітинна компонента | • цитоплазма
• нуклеоплазма
• клітинне ядро
• RNA polymerase II transcription regulator complex
|
|---|
| Біологічний процес | • positive regulation of high-density lipoprotein particle assembly
• negative regulation of proteolysis
• positive regulation of triglyceride biosynthetic process
• GO:0051247, GO:0051200 positive regulation of protein metabolic process
• negative regulation of interferon-gamma-mediated signaling pathway
• positive regulation of cholesterol transport
• GO:0009373 regulation of transcription, DNA-templated
• cellular lipid metabolic process
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• positive regulation of secretion of lysosomal enzymes
• positive regulation of lipid storage
• positive regulation of lipoprotein lipase activity
• GO:1901227 negative regulation of transcription by RNA polymerase II
• positive regulation of fatty acid biosynthetic process
• negative regulation of gene expression
• transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• negative regulation of cholesterol storage
• negative regulation of pinocytosis
• GO:1901313 positive regulation of gene expression
• retinoic acid receptor signaling pathway
• positive regulation of cholesterol efflux
• positive regulation of pancreatic juice secretion
• lipid homeostasis
• negative regulation of lipid transport
• transcription initiation from RNA polymerase II promoter
• GO:0045996 negative regulation of transcription, DNA-templated
• negative regulation of macrophage derived foam cell differentiation
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• steroid hormone mediated signaling pathway
• cholesterol homeostasis
• lipid metabolism
• multicellular organism development
• диференціація клітин
• cellular response to lipopolysaccharide
• negative regulation of cold-induced thermogenesis
• intracellular receptor signaling pathway
|
|---|
| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
|---|
 |
| Більше даних |
| Ортологи |
|---|
| Види | Людина | Миша |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (мРНК) | | | NM_001285517
NM_001285518
NM_001285519
NM_009473 |
|
|---|
| RefSeq (білок) | | NP_001243576
NP_009052
NP_009052.3 |
| | NP_001272446
NP_001272447
NP_001272448
NP_033499 |
|
|---|
| Локус (UCSC) | Хр. 19: 50.33 – 50.38 Mb | Хр. 7: 44.2 – 44.2 Mb |
|---|
| PubMed search | [2] | [3] |
|---|
| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
|
