| MAX |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1AN2, 1HLO, 1NKP, 1NLW, 1R05 | | |
| Ідентифікатори |
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| Символи | MAX, bHLHd4, max, MYC associated factor X |
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| Зовнішні ІД | OMIM: 154950 MGI: 96921 HomoloGene: 1786 GeneCards: MAX |
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| Пов'язані генетичні захворювання |
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| феохромоцитома, hereditary pheochromocytoma-paraganglioma, adrenal gland pheochromocytoma[1] |
| Онтологія гена |
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| Молекулярна функція | • sequence-specific DNA binding
• protein dimerization activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001105 transcription coactivator activity
• GO:0001104 transcription coregulator activity
• GO:0000983 RNA polymerase II general transcription initiation factor activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001948, GO:0016582 protein binding
• DNA binding
• protein homodimerization activity
• E-box binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0032403 protein-containing complex binding
• protein heterodimerization activity
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| Клітинна компонента | • PML body
• cell projection
• дендрит (нейробіологія)
• клітинне ядро
• нуклеоплазма
• цитоплазма
• protein-DNA complex
• MLL1 complex
• RNA polymerase II transcription regulator complex
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| Біологічний процес | • neuron apoptotic process
• GO:0009373 regulation of transcription, DNA-templated
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• cellular response to starvation
• transcription by RNA polymerase II
• negative regulation of gene expression
• transcription, DNA-templated
• response to insulin
• cellular response to peptide hormone stimulus
• retina development in camera-type eye
• response to axon injury
• response to organonitrogen compound
• GO:1901227 negative regulation of transcription by RNA polymerase II
• negative regulation of G0 to G1 transition
• G1/S transition of mitotic cell cycle
• GO:0034622 protein-containing complex assembly
• positive regulation of nucleic acid-templated transcription
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | NM_001271068
NM_001271069
NM_002382
NM_145112
NM_145113
| NM_145114
NM_145116
NM_197957
NM_001320415 |
| | NM_001146176
NM_008558
NM_001361663
NM_001361664 |
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| RefSeq (білок) | NP_001257997
NP_001257998
NP_001307344
NP_002373
NP_660087
| NP_660088
NP_660089
NP_932061
NP_002373.3
NP_660087.1
NP_660088.1
NP_001307344.1 |
| | NP_001139648
NP_001348592
NP_001348593
NP_032584 |
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| Локус (UCSC) | Хр. 14: 65.01 – 65.1 Mb | Хр. 12: 76.98 – 77.01 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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